There are many clinical settings where full thickness skin wounds occur. Wounds will differ significantly based upon surface diameter, depth of wound, location of wound and clinical setting which include:
- Reconstructive surgery following skin cancer, traumatic wounds or amputation;
- Chronic wounds such as diabetic foot ulcers or venous stasis;
- Severe burns; and
- Other such as cosmetic surgery scar revision.
Clinical classification of wounds is generally based upon their depth and the associated damage or on their etiology such as surgical, traumatic, burns, ulcer related or carcinoma. The classification usually influences the type of wound treatment, including product selection. With a growing and ageing population, rising demand driven by data-empowered consumers, obesity and increased incidence of diabetes, the demand for portable and easy to use devices is increasing among patients and surgeons. However, reimbursement cuts and pricing constraints continue to place considerable pressures on the healthcare industry.
There are three main stages in wound healing:
- Inflammation phase. The natural response of the body to injuries. After haemostasis (stopping of the bleeding) is achieved, blood vessels get dilated and growth factors, nutrients etc. spread across the wounded area.
- Proliferation phase. New granulation tissue, containing collagen and extra-cellular matrix, are formed along with a new network of blood vessels (angiogenesis).
- Maturation phase. After the wound is closed the fibroblast cells start to remodel the dermal tissue around the wound.
Currently, it is estimated that there are around 50 million reported cases globally of patients suffering from hard-to-close wounds, which has created a severe cost burden to the global healthcare system.
Advanced biomaterial scaffolds, such as Smart Matrix® have been designed to prevent disruption of the body’s natural healing process and support tissue regeneration.
Smart Matrix Limited is about to carry out further clinical testing which, it is expected, will demonstrate that use of Smart Matrix® can avoid the need for some surgical interventions and demonstrate its applicability in a wide range of wound types and clinical indications due to its unique physical composition which offers an optimal balance of the following properties:
- Porosity allowing cell ingress
- Degredation that parallels wound healing
- Adherence/rapid integration
- Ease of use
- Cost effectiveness
Smart Matrix Limited - Winners of the 2016 International Life Sciences Award for Best Medical Implant & Technology Research Group
Smart Matrix Limited – Winner of the 2016 ACQ5 Global Award for UK Gamechanger of the Year – Ms Leonor Stjepic
Smart Matrix Limited – Winner of the 2016 ACQ5 Global Award for UK - Company of the Year
Smart Matrix Limited – Winner of the 2016 Healthcare and Life Sciences Award